General description

Somatostatin is a peptide hormone widely distributed throughout the body and is an important regulator of endocrine and nervous system function. Somatostatin can also be found in gastrointestinal and bronchopulmonary endocrine cells, thymic endocrine cells, and thyroid C-cells. Anti-somatostatin is a useful marker of D-cells of pancreatic islet cells.1,2 D-cells identification can be used to identify hyperplasia of the pancreatic islets of Langerhans and tumors arising from these cells. Anti-somatostatin recognizes somatostatin-containing cells in pancreatic tumors, islet cell hyperplasia, and islet cells originating in pancreatic ductules.3-7

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Somatostatin Positive Control Slides, Product No. 332S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality